A major collision took place around 12:15 p.m. on southbound Highway 101 between Whipple and Woodside roads in Redwood City.
California Highway Patrol (CHP) reports indicate at least 4-5 vehicles were involved. One vehicle ended up facing the wrong way.
Firetrucks and CHP officers were still at the scene in the early afternoon, and at least two of the vehicles were being towed away due to major damage.
Traffic was backed up past Holly Street.
Patch will update this story as more information becomes available.